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| 1. |  | SOUZA, S. F. de; PARAHYBA, R. da B. V.; CAVALCANTI, L. C. de S.; LIRA, D. R. de; ARAÚJO, M. do S. B. de. Mapeamento geomorfológico da Bacia do Brígida no sertão pernambucano, através de aplicações geotecnológicas. In: SIMPÓSIO NACIONAL DE GEOMORFOLOGIA, 8., 2010, Recife. Anais... Recife: UFPE, 2010.| Biblioteca(s): Embrapa Solos. |
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| 2. | | SOUZA, S. F. de; PARAHYBA, R. da B. V.; CAVALCANTI, L. C. de S.; LIRA, D. R. de; ARAÚJO, M. do S. B. de. Mapeamento geomorfológico da Bacia do Brígida no sertão pernanbucano, através de aplicações geotecnológicas. In: SIMPÓSIO NACIONAL DE GEOMORFOLOGIA, 8., 2010, Recife, PE. Anais... Recife, PE: UFPE, 2010.| Biblioteca(s): Embrapa Solos / UEP-Recife. |
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| Registros recuperados : 2 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
19/11/2013 |
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Data da última atualização: |
05/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
UTSUNOMIYA, Y. T.; CARMO, A. S. do; CARVALHEIRO, R.; NEVES, H. H. R.; MATOS, M. C.; ZAVAREZ, L. B.; O'BRIEN, A. M. P.; SÖLKNER, J.; McEWAN, J. C.; COLE, J. B.; TASSEL, C. P. V.; SCHENKEL, F. S.; SILVA, M. V. G. B.; PORTO NETO, L. R.; SONSTEGARD, T. S.; GARCIA, J. F. |
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Afiliação: |
YURI T. UTSUNOMIYA, UNESP; ADRIANA S. DO CARMO, UNESP; ROBERTO CARVALHEIRO, GenSys Consultores Associados; HAROLDO H. R. NEVES, UNESP; MÁRCIA C. MATOS, UNESP; LUDMILLA B. ZAVAREZ, UNESP; ANA M. PÉREZ O'BRIEN, University of Natural Resources and Life Sciences, Vienna; JOHANN SÖLKNER, University of Natural Resources and Life Sciences, Vienna; JOHN C. McEWAN, Centre for Reproduction and Genomics, AgResearch, Mosgiel, New Zealand; JOHN B. COLE, ARS-USDA, USA; CURTIS P. VAN TASSEL, ARS-USDA, USA; FLÁVIO S. SCHENKEL, University of Guelph, Canada; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; LAERCIO R. PORTO NETO, University of Queensland, Australia; University of New England, Australia; TAD S. SONSTEGARD, ARS-USDA, USA; JOSÉ F. GARCIA, UNESP. |
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Título: |
Genome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
BMC Genetics, London, v. 14, article 52, 2013. |
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DOI: |
https://doi.org/10.1186/1471-2156-14-52 |
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Idioma: |
Inglês |
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Conteúdo: |
Background - Birth weight (BW) is an economically important trait in beef cattle, and is associated with growth- and stature-related traits and calving difficulty. One region of the cattle genome, located on Bos primigenius taurus chromosome 14 (BTA14), has been previously shown to be associated with stature by multiple independent studies, and contains orthologous genes affecting human height. A genome-wide association study (GWAS) for BW in Brazilian Nellore cattle (Bos primigenius indicus) was performed using estimated breeding values (EBVs) of 654 progeny-tested bulls genotyped for over 777,000 single nucleotide polymorphisms (SNPs). Results - The most significant SNP (rs133012258, PGC = 1.34 × 10-9), located at BTA14:25376827, explained 4.62% of the variance in BW EBVs. The surrounding 1 Mb region presented high identity with human, pig and mouse autosomes 8, 4 and 4, respectively, and contains the orthologous height genes PLAG1, CHCHD7, MOS, RPS20, LYN, RDHE2 (SDR16C5) and PENK. The region also overlapped 28 quantitative trait loci (QTLs) previously reported in literature by linkage mapping studies in cattle, including QTLs for birth weight, mature height, carcass weight, stature, pre-weaning average daily gain, calving ease, and gestation length. Conclusions- This study presents the first GWAS applying a high-density SNP panel to identify putative chromosome regions affecting birth weight in Nellore cattle. These results suggest that the QTLs on BTA14 associated with body size in taurine cattle (Bos primigenius taurus) also affect birth weight and size in zebu cattle (Bos primigenius indicus). MenosBackground - Birth weight (BW) is an economically important trait in beef cattle, and is associated with growth- and stature-related traits and calving difficulty. One region of the cattle genome, located on Bos primigenius taurus chromosome 14 (BTA14), has been previously shown to be associated with stature by multiple independent studies, and contains orthologous genes affecting human height. A genome-wide association study (GWAS) for BW in Brazilian Nellore cattle (Bos primigenius indicus) was performed using estimated breeding values (EBVs) of 654 progeny-tested bulls genotyped for over 777,000 single nucleotide polymorphisms (SNPs). Results - The most significant SNP (rs133012258, PGC = 1.34 × 10-9), located at BTA14:25376827, explained 4.62% of the variance in BW EBVs. The surrounding 1 Mb region presented high identity with human, pig and mouse autosomes 8, 4 and 4, respectively, and contains the orthologous height genes PLAG1, CHCHD7, MOS, RPS20, LYN, RDHE2 (SDR16C5) and PENK. The region also overlapped 28 quantitative trait loci (QTLs) previously reported in literature by linkage mapping studies in cattle, including QTLs for birth weight, mature height, carcass weight, stature, pre-weaning average daily gain, calving ease, and gestation length. Conclusions- This study presents the first GWAS applying a high-density SNP panel to identify putative chromosome regions affecting birth weight in Nellore cattle. These results suggest that the QTLs on BTA14 associated with ... Mostrar Tudo |
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Palavras-Chave: |
Bos primigenius indicus; GWAS; Nellore cattle; Stature. |
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Thesaurus NAL: |
birth weight. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
LEADER 02754naa a2200373 a 4500
001 1971572
005 2024-02-05
008 2013 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1186/1471-2156-14-52$2DOI
100 1 $aUTSUNOMIYA, Y. T.
245 $aGenome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height.$h[electronic resource]
260 $c2013
520 $aBackground - Birth weight (BW) is an economically important trait in beef cattle, and is associated with growth- and stature-related traits and calving difficulty. One region of the cattle genome, located on Bos primigenius taurus chromosome 14 (BTA14), has been previously shown to be associated with stature by multiple independent studies, and contains orthologous genes affecting human height. A genome-wide association study (GWAS) for BW in Brazilian Nellore cattle (Bos primigenius indicus) was performed using estimated breeding values (EBVs) of 654 progeny-tested bulls genotyped for over 777,000 single nucleotide polymorphisms (SNPs). Results - The most significant SNP (rs133012258, PGC = 1.34 × 10-9), located at BTA14:25376827, explained 4.62% of the variance in BW EBVs. The surrounding 1 Mb region presented high identity with human, pig and mouse autosomes 8, 4 and 4, respectively, and contains the orthologous height genes PLAG1, CHCHD7, MOS, RPS20, LYN, RDHE2 (SDR16C5) and PENK. The region also overlapped 28 quantitative trait loci (QTLs) previously reported in literature by linkage mapping studies in cattle, including QTLs for birth weight, mature height, carcass weight, stature, pre-weaning average daily gain, calving ease, and gestation length. Conclusions- This study presents the first GWAS applying a high-density SNP panel to identify putative chromosome regions affecting birth weight in Nellore cattle. These results suggest that the QTLs on BTA14 associated with body size in taurine cattle (Bos primigenius taurus) also affect birth weight and size in zebu cattle (Bos primigenius indicus).
650 $abirth weight
653 $aBos primigenius indicus
653 $aGWAS
653 $aNellore cattle
653 $aStature
700 1 $aCARMO, A. S. do
700 1 $aCARVALHEIRO, R.
700 1 $aNEVES, H. H. R.
700 1 $aMATOS, M. C.
700 1 $aZAVAREZ, L. B.
700 1 $aO'BRIEN, A. M. P.
700 1 $aSÖLKNER, J.
700 1 $aMcEWAN, J. C.
700 1 $aCOLE, J. B.
700 1 $aTASSEL, C. P. V.
700 1 $aSCHENKEL, F. S.
700 1 $aSILVA, M. V. G. B.
700 1 $aPORTO NETO, L. R.
700 1 $aSONSTEGARD, T. S.
700 1 $aGARCIA, J. F.
773 $tBMC Genetics, London$gv. 14, article 52, 2013.
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